IDUA Polyclonal Antibody for Human(Homo sapiens) | EIAab.comIDUA Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > IDUA(Gene name) > Human

IDUA (Gene name),

Alpha-L-iduronidase (Protein name ), IDUA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IDUA;

Protein name:

Alpha-L-iduronidase;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

N/A

Subcellular Location:

Lysosome

Protein Attributes:

Sequence length:

653

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

653:

GNP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

252800

Pfam:

PF01229

UniGene:

Hs.89560

String:

P35475

SMR:

P35475

KEGG:

hsa:3425

STRING:

9606.ENSP00000247933

Uniprot:

P35475

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ELISA Kit for Human Alpha-L-iduronidase

Cat.:

E0169h

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Packing:

96T

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ELISA Kit for Human Alpha-L-iduronidase

Cat.:

E0169m

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Manual:

Looking for manual.

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Packing:

96T

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ELISA Kit for Human Alpha-L-iduronidase

Cat.:

E0169d

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Packing:

96T

CLIA Kit for Human Alpha-L-iduronidase

Cat.:

U0169m

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Packing:

96T

CLIA Kit for Human Alpha-L-iduronidase

Cat.:

U0169h

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MSDS:

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Packing:

96T

CLIA Kit for Human Alpha-L-iduronidase

Cat.:

U0169d

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Packing:

96T

Polyclonal Antibody for Human Alpha-L-iduronidase

Cat.:

P0169Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Alpha-L-iduronidase

Cat.:

P0169Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Alpha-L-iduronidase

Monoclonal Antibody for Human Alpha-L-iduronidase

Protein for Human Alpha-L-iduronidase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human alpha-L-iduronidase: cDNA isolation and expression."
Scott H.S. , Anson D.S. , Orsborn A.M. , Nelson P.V. , Clements P.R. , Morris C.P. , Hopwood J.J.
Proc. Natl. Acad. Sci. U.S.A.88:9695-9699(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLN-33
tissue: Liver.
2.

"Structure and sequence of the human alpha-L-iduronidase gene."
Scott H.S. , Guo X.H. , Hopwood J.J. , Morris C.P.
Genomics13:1311-1313(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLN-33
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
4.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"Molecular genetics of mucopolysaccharidosis type I: diagnostic, clinical, and biological implications."
Scott H.S. , Bunge S. , Gal A. , Clarke L.A. , Morris C.P. , Hopwood J.J.
Hum. Mutat.6:288-302(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
6.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110
tissue: Liver.
7.

"Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase."
Bie H. , Yin J. , He X. , Kermode A.R. , Goddard-Borger E.D. , Withers S.G. , James M.N.
Nat. Chem. Biol.9:739-745(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 27-653 IN COMPLEX WITH IDURONATE ANALOGS;CATALYTIC ACTIVITY;ACTIVE SITE;CHARACTERIZATION OF VARIANT MPS1H ARG-533;DISULFIDE BOND;GLYCOSYLATION AT ASN-110; ASN-372 AND ASN-415
8.

"Human alpha-L-iduronidase uses its own N-glycan as a substrate-binding and catalytic module."
Maita N. , Tsukimura T. , Taniguchi T. , Saito S. , Ohno K. , Taniguchi H. , Sakuraba H.
Proc. Natl. Acad. Sci. U.S.A.110:14628-14633(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 27-653 IN COMPLEX WITH IDURONATE;CATALYTIC ACTIVITY;DISULFIDE BOND;SUBUNIT;GLYCOSYLATION AT ASN-110; ASN-372; ASN-415 AND ASN-451;IDENTIFICATION BY MASS SPECTROMETRY
9.

"Mutation analysis of 19 North American mucopolysaccharidosis type I patients: identification of two additional frequent mutations."
Clarke L.A. , Nelson P.V. , Warrington C.L. , Morris C.P. , Hopwood J.J. , Scott H.S.
Hum. Mutat.3:275-282(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPS1H THR-75
10.

"Two novel mutations causing mucopolysaccharidosis type I detected by single strand conformational analysis of the alpha-L-iduronidase gene."
Clark L.A. , Scott H.S.
Hum. Mol. Genet.2:1311-1312(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPS1H/S PRO-82
11.

"Identification of mutations in the alpha-L-iduronidase gene (IDUA) that cause Hurler and Scheie syndromes."
Scott H.S. , Litjens T. , Nelson P.V. , Thompson P.R. , Brooks D.A. , Hopwood J.J. , Morris C.P.
Am. J. Hum. Genet.53:973-986(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPS1S GLN-89
12.

"Molecular analysis of Hurler syndrome in Druze and Muslim Arab patients in Israel: multiple allelic mutations of the IDUA gene in a small geographic area."
Bach G. , Moskowitz S.M. , Tieu P.T. , Matynia A. , Neufeld E.F.
Am. J. Hum. Genet.53:330-338(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MPS1H PRO-366 AND ARG-409
13.

"Alpha-L-iduronidase mutations (Q70X and P533R) associate with a severe Hurler phenotype."
Scott H.S. , Litjens T. , Nelson P.V. , Brooks D.A. , Hopwood J.J. , Morris C.P.
Hum. Mutat.1:333-339(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPS1H ARG-533
14.

"Mucopolysaccharidosis type I: identification of 8 novel mutations and determination of the frequency of the two common alpha-L-iduronidase mutations (W402X and Q70X) among European patients."
Bunge S. , Kleijer W.J. , Steglich C. , Beck M. , Zuther C. , Morris C.P. , Schwinger E. , Hopwood J.J. , Scott H.S. , Gal A.
Hum. Mol. Genet.3:861-866(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MPS1H ASP-51; THR-75; PRO-218; PRO-327; PRO-489 AND 16-SER--ALA-19 DEL
15.

"PCR detection of two RFLPs in exon I of the alpha-L-iduronidase (IDUA) gene."
Scott H.S. , Litjens T. , Hopwood J.J. , Morris C.P.
Hum. Genet.90:327-327(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLN-33
16.

"Multiple polymorphisms within the alpha-L-iduronidase gene (IDUA): implications for a role in modification of MPS-I disease phenotype."
Scott H.S. , Nelson P.V. , Litjens T. , Hopwood J.J. , Morris C.P.
Hum. Mol. Genet.2:1471-1473(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-361
17.

"Four novel mutations underlying mild or intermediate forms of alpha-L-iduronidase deficiency (MPS IS and MPS IH/S)."
Tieu P.T. , Bach G. , Matynia A. , Hwang M. , Neufeld E.F.
Hum. Mutat.6:55-59(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MPS1H/S PRO-490 AND LEU-496;VARIANT MPS1S PRO-492
18.

"Mucopolysaccharidosis type I: identification of 13 novel mutations of the alpha-L-iduronidase gene."
Bunge S. , Kleijer W.J. , Steglich C. , Beck M. , Schwinger E. , Gal A.
Hum. Mutat.6:91-94(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MPS1S TRP-89 AND HIS-383;VARIANT MPS1H 349-ASP-ASN-350 DEL;VARIANTS MPS1H/S THR-504 AND ARG-626
19.

"Molecular genetic defect underlying alpha-L-iduronidase pseudodeficiency."
Aronovich E.L. , Pan D. , Whitley C.B.
Am. J. Hum. Genet.58:75-85(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IDUA PSEUDODEFICIENCY THR-300
20.

"A novel missense mutation in the human IDUA gene associated with a severe Hurler's phenotype."
Bartholomew D.W. , McClellan J.M.
Hum. Mutat.12:291-291(1998)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPS1H ARG-388
21.

"Mucopolysaccharidosis type I: characterization of novel mutations affecting alpha-L-iduronidase activity."
Lee-Chen G.J. , Lin S.P. , Tang Y.F. , Chin Y.W.
Clin. Genet.56:66-70(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPS1H/S GLY-619
22.

"Identification and characterization of -3c-g acceptor splice site mutation in human alpha-L-iduronidase associated with mucopolysaccharidosis type IH/S."
Teng Y.N. , Wang T.R. , Hwu W.L. , Lin S.P. , Lee-Chen G.J.
Clin. Genet.57:131-136(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPS1H/S ARG-346
23.

"Identification and characterization of 13 new mutations in mucopolysaccharidosis type I patients."
Matte U. , Yogalingam G. , Brooks D. , Leistner S. , Schwartz I. , Lima L. , Norato D.Y. , Brum J.M. , Beesley C. , Winchester B. , Giugliani R. , Hopwood J.J.
Mol. Genet. Metab.78:37-43(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MPS1H ILE-133; LYS-182; ASP-208; TYR-349 AND ARG-533;VARIANTS MPS1H/S PHE-260; PRO-327; ARG-380 AND PRO-628;VARIANTS MPS1S GLN-89; ILE-350; HIS-383 AND ASP-445 DEL
24.

"Identification and molecular characterization of alpha-L-iduronidase mutations present in mucopolysaccharidosis type I patients undergoing enzyme replacement therapy."
Yogalingam G. , Guo X.H. , Muller V.J. , Brooks D.A. , Clements P.R. , Kakkis E.D. , Hopwood J.J.
Hum. Mutat.24:199-207(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MPS1H/S VAL-79; GLN-238; PRO-327; CYS-363; ARG-380; ARG-533 AND ILE-602;VARIANT MPS1S ARG-423;VARIANTS GLN-82; GLN-105; THR-361 AND ILE-454;CHARACTERIZATION OF VARIANTS MPS1H/S VAL-79; GLN-238; CYS-363 AND ILE-602;CHARACTERIZATION OF VARIANT MPS1S ARG-423;CHARACTERIZATION OF VARIANT GLN-82
25.

"IDUA mutational profiling of a cohort of 102 European patients with mucopolysaccharidosis type I: identification and characterization of 35 novel alpha-L-iduronidase (IDUA) alleles."
Bertola F. , Filocamo M. , Casati G. , Mort M. , Rosano C. , Tylki-Szymanska A. , Tuysuz B. , Gabrielli O. , Grossi S. , Scarpa M. , Parenti G. , Antuzzi D. , Dalmau J. , Di Rocco M. , Vici C.D. , Okur I. , Rosell J. , Rovelli A. , more...
Hum. Mutat.32:E2189-E2210(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MPS1H/S ARG-84; LYS-178; LEU-188; ARG-265; LYS-276; ARG-423; PRO-436; ARG-496; ARG-533 AND PHE-535;VARIANTS MPS1H ASP-51; PRO-103; PRO-327 AND ARG-385;VARIANTS MPS1S CYS-76; TRP-89; GLU-219; LYS-276; LEU-306; LYS-348; PRO-490 AND PRO-492;VARIANT MPS1 PRO-396;VARIANTS GLN-33; GLN-105; THR-361; ASN-449; ILE-454 AND THR-591

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